pVACtools is a cancer immunotherapy tools suite consisting of the following tools:

A cancer immunotherapy pipeline for identifying and prioritizing neoantigens from a list of tumor mutations.
A tool for detecting neoantigens resulting from gene fusions.
A tool designed to aid specifically in the construction of DNA-based cancer vaccines.
pVACtools immunotherapy workflow

New in version 1.0.8

This is a hotfix release. It fixes the following issues:

  • The log directories were accidentially included with the pVACseq example data. They are now removed.
  • Some users were reporting mixed type warnings for pandas when running pVACseq. We added some options to avoid this warning.

Coming soon

A browser-based user interface that assists users in launching, managing, reviewing, and visualizing the results of pVACtools processes.
The pVACapi will provide a HTTP REST interface to the pVACtools suite.


Jasreet Hundal, Beatriz M. Carreno, Allegra A. Petti, Gerald P. Linette, Obi L. Griffith, Elaine R. Mardis, and Malachi Griffith. pVACseq: A genome-guided in silico approach to identifying tumor neoantigens. Genome Medicine. 2016, 8:11, DOI: 10.1186/s13073-016-0264-5. PMID: 26825632.


This project is licensed under NPOSL-3.0.